Please use this identifier to cite or link to this item: https://hdl.handle.net/10419/243683 
Year of Publication: 
2019
Citation: 
[Journal:] Energy Reports [ISSN:] 2352-4847 [Volume:] 5 [Publisher:] Elsevier [Place:] Amsterdam [Year:] 2019 [Pages:] 1426-1431
Publisher: 
Elsevier, Amsterdam
Abstract: 
Current water treatment methods are unable to eliminate artificial sweeteners, which can lead to their accumulation in the environment. Due to this problem, natural sweeteners can be used instead, but it is important to understand their effects in biological systems. Rebaudioside A, one of the main components of stevia, causes an increase in both ROS and in FAD linked autofluorescence in hippocampal CA3 area. These effects may be due to the insulin-mimetic properties of steviol glycosides, suggesting the results that they cause enhancements in glycolysis and in OXPHOS, with this metabolic pathway being the source of the rise in ROS. In excess, these molecules may cause damage to brain cells through oxidative stress. As leftovers from Stevia's purification process can be used as biomass, with applications ranging from energy production to fertilization, continuous accumulation in the environment should be avoided in order to prevent undesired effects in the ecosystem.
Subjects: 
Autofluorescence
CA3
OXPHOS
Reactive oxygen species
Rebaudioside A
Stevia
Persistent Identifier of the first edition: 
Creative Commons License: 
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Document Type: 
Article
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