Please use this identifier to cite or link to this item: http://hdl.handle.net/10419/230005
Authors: 
Andrews, Ryan M.
Shpitser, Ilya
Lopez, Oscar
Longstreth, William T.
Chaves, Paulo H. M.
Kuller, Lewis
Carlson, Michelle C.
Year of Publication: 
2020
Citation: 
[Journal:] Journal of the Royal Statistical Society: Series A (Statistics in Society) [ISSN:] 1467-985X [Volume:] 183 [Issue:] 4 [Pages:] 1705-1726
Abstract: 
The paper examines whether diabetes mellitus leads to incident mild cognitive impairment and dementia through brain hypoperfusion and white matter disease. We performed inverse odds ratio weighted causal mediation analyses to decompose the effect of diabetes on cognitive impairment into direct and indirect effects, and we found that approximately a third of the total effect of diabetes is mediated through vascularÔÇÉrelated brain pathology. Our findings lend support for a common aetiological hypothesis regarding incident cognitive impairment, which is that diabetes increases the risk of clinical cognitive impairment in part by impacting the vasculature of the brain.
Subjects: 
Alzheimer's disease
Causal inference
Causal mediation analysis
Cognitive neuroscience
Public health
Persistent Identifier of the first edition: 
Creative Commons License: 
http://creativecommons.org/licenses/by/4.0/
Document Type: 
Article
Document Version: 
Published Version

Files in This Item:
File
Size





Items in EconStor are protected by copyright, with all rights reserved, unless otherwise indicated.