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Andrews, Ryan M.
Shpitser, Ilya
Lopez, Oscar
Longstreth, William T.
Chaves, Paulo H. M.
Kuller, Lewis
Carlson, Michelle C.
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[Journal:] Journal of the Royal Statistical Society: Series A (Statistics in Society) [ISSN:] 1467-985X [Volume:] 183 [Issue:] 4 [Pages:] 1705-1726
The paper examines whether diabetes mellitus leads to incident mild cognitive impairment and dementia through brain hypoperfusion and white matter disease. We performed inverse odds ratio weighted causal mediation analyses to decompose the effect of diabetes on cognitive impairment into direct and indirect effects, and we found that approximately a third of the total effect of diabetes is mediated through vascularÔÇÉrelated brain pathology. Our findings lend support for a common aetiological hypothesis regarding incident cognitive impairment, which is that diabetes increases the risk of clinical cognitive impairment in part by impacting the vasculature of the brain.
Alzheimer's disease
Causal inference
Causal mediation analysis
Cognitive neuroscience
Public health
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