A number of recent studies in the economics literature have focused on the usefulness of factor models in the context of prediction using big data. In this paper, our over-arching question is whether such big data are useful for modelling low frequency macroeconomic variables such as unemployment, inflation and GDP. In particular, we analyze the predictive benefits associated with the use dimension reducing independent component analysis (ICA) and sparse principal component analysis (SPCA), coupled with a variety of other factor estimation as well as data shrinkage methods, including bagging, boosting, and the elastic net, among others. We do so by carrying out a forecasting horse-race, involving the estimation of 28 different baseline model types, each constructed using a variety of specification approaches, estimation approaches, and benchmark econometric models; and all used in the prediction of 11 key macroeconomic variables relevant for monetary policy assessment. In many instances, we find that various of our benchmark specifications, including autoregressive (AR) models, AR models with exogenous variables, and (Bayesian) model averaging, do not dominate more complicated nonlinear methods, and that using a combination of factor and other shrinkage methods often yields superior predictions. For example, simple averaging methods are mean square forecast error (MSFE) best in only 9 of 33 key cases considered. This is rather surprising new evidence that model averaging methods do not necessarily yield MSFE-best predictions. However, in order to beat model averaging methods, including arithmetic mean and Bayesian averaging approaches, we have introduced into our horse-race numerous complex new models involve combining complicated factor estimation methods with interesting new forms of shrinkage. For example, SPCA yields MSFE-best prediction models in many cases, particularly when coupled with shrinkage. This result provides strong new evidence of the usefulness of sophisticated factor based forecasting, and therefore, of the use of big data in macroeconometric forecasting.