Nauman, Ahmad Tauseef Behlouli, Hassan Alexander, Nicholas Kendel, Friederike Drewelies, Johanna Mantantzis, Konstantinos Berger, Nora Wagner, Gert G. Gerstorf, Denis Demuth, Ilja Pilote, Louise Regitz-Zagrosek, Vera
Year of Publication:
[Journal:] Biology of Sex Differences [ISSN:] 2042-6410 [Year:] 2021 [Issue:] 12 (Article No.:) 15
In addition to biological sex, gender, defined as the sociocultural dimension of being a woman or a man, plays a central role in health. However, there are so far few approaches to quantify gender in a retrospective manner in existing study datasets. We therefore aimed to develop a methodology that can be retrospectively applied to assess gender in existing cohorts. We used baseline data from the Berlin Aging Study II (BASE-II), obtained in 2009–2014 from 1869 participants aged 60 years and older. We identified 13 gender-related variables and used them to construct a gender score by using primary component and logistic regression analyses. Of these, nine variables contributed to a gender score: chronic stress, marital status, risk-taking behaviour, personality attributes: agreeableness, neuroticism, extraversion, loneliness, conscientiousness, and level of education. Females and males differed significantly in the distribution of the gender score, but a significant overlap was also found. Thus, we were able to develop a gender score in a retrospective manner from already collected data that characterized participants in addition to biological sex. This approach will allow researchers to introduce the notion of gender retrospectively into a large number of studies.
Gender Sex Aging Berlin Aging Study II Base-II Gender score