This descriptive paper is part of a large project aiming at exploring the factors determining the propensity of Swiss science institutions to interact with private enterprises in Switzerland (universities and other research institution), i.e. to get involved in knowledge and technology transfer (KTT) activities. On the other hand, a second part of this project investigates the factors determining the propensity of Swiss private enterprises for KTT activities. We are especially interested in the different forms of this interaction, not only through joint research projects but also through training, mobility of academic personnel, jointly supervised master theses and PhDs, consulting and so on. Further, our study investigates the channels of KTT such as e.g. scientific publications, patents, spin-offs as well as the mediating institutions (e.g. Technology Transfer Offices, Commission for Technology and Innovation (KTI), Swiss Research Foundation (SNF)). We also discuss the relative importance of a series of motives for and impediments of KTT activities. Finally, we take also a look at the impact of KTT activities on the research orientation, on teaching and least but not last, the financial position of institutes co-orating with private enterprises.