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Dette, Holger
Scheder, Regine
Year of Publication: 
Series/Report no.: 
Technical Report No. 2008,05
To estimate the effective dose level ED a in the common binary response model, several parametric and nonparametric estimators have been proposed in the literature. In the present paper, we focus on nonparametric methods and present a detailed numerical comparison of four different approaches to estimate the ED a nonparametrically. The methods are briefly reviewed and their finite sample properties are studied by means of a detailed simulation study. Moreover, a data example is presented to illustrate the different concepts.
Binary response model
effective dose level
nonparametric regression
isotonic regression
order restricted inference
local linear regression
Document Type: 
Working Paper

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