Bitte verwenden Sie diesen Link, um diese Publikation zu zitieren, oder auf sie als Internetquelle zu verweisen: https://hdl.handle.net/10419/25007 
Erscheinungsjahr: 
2007
Schriftenreihe/Nr.: 
Technical Report No. 2007,22
Verlag: 
Universität Dortmund, Sonderforschungsbereich 475 - Komplexitätsreduktion in Multivariaten Datenstrukturen, Dortmund
Zusammenfassung: 
In this paper, we describe an adjusted method to facilitate a non-inferiority trial by a three-arm robust design. Because local optimal designs derived in Hasler et al. [2007] require knowledge about the ratios of the population variances and are not necessarily robust with respect to possible misspecifications, a maximin approach is adopted. This method requires only the specification of an interval for the of variance ratios and yields robust and efficient designs. We demonstrate that a maximin optimal design only depends on the boundary points specified for the intervals of the variance ratios and receive numerical and analytical solutions. The derived designs are robust and very efficient for statistical analysis in non inferiority three arm trials.
Schlagwörter: 
maximin design
robust design
non-inferiority
three arm design
gold design trials
randomized clinical trial
Dokumentart: 
Working Paper

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