Technical Report / Universität Dortmund, SFB 475 Komplexitätsreduktion in Multivariaten Datenstrukturen 2005,08
In dose-response studies, the dose range is often restricted due to concerns over drug toxicity and/or efficacy. We derive optimal designs for estimating the underlying dose-response curve for a restricted or unrestricted dose range with respect to a broad class of optimality criteria. The underlying curve belongs to a diversified set of link functions suitable for the dose response studies and having a common canonical form. These include the fundamental binary response models – the logit and the probit as well as the skewed versions of these models. Our methodology is based on a new geometric interpretation of optimal designs with respect to Kiefer?s [Omega]p-criteria in regression models with two parameters, which is of independent interest. It provides an intuitive illustration of the number and locations of the support points of [Omega]p-optimal designs. Moreover, the geometric results generalize the classical characterization of D-optimal designs by the minimum covering ellipsoid [see Silvey (1972) or Sibson (1972)] to the class of Kiefer?s [Omega]p-criteria. The results are illustrated through the re-design of a dose ranging trial.
Binary response model Dose ranging Dose-response Dual problem Link function Locally compound optimal design Minimum ellipse