Please use this identifier to cite or link to this item: http://hdl.handle.net/10419/22552
Authors: 
Dette, Holger
Biedermann, Stefanie
Zhu, Wei
Year of Publication: 
2004
Series/Report no.: 
Technical Report / Universität Dortmund, SFB 475 Komplexitätsreduktion in Multivariaten Datenstrukturen 2004,40
Abstract: 
In dose response studies, the dose range is often restricted due to concerns over drug toxicity and/or efficacy. We present restricted and unrestricted interval locally optimal designs with respect to a very general class of optimality criteria for estimating the underlying dose response curve. The underlying curve belongs to a diversified set of link functions suitable for the dose response studies and having a common canonical form. These include the fundamental binary response models – the logit and the probit as well as the skewed versions of these models. The results are illustrated through the re-design of a dose ranging trial conducted at the Merck Research Laboratories (Zeng and Zhu, 1997). This work is a generalization of the results of Dai and Zhu (2002) in terms of the design interval, the underlying dose response curve and the optimality criterion.
Subjects: 
Binary response model
Dose ranging
Dose response
Link function
General Equivalence Theorem
Locally compound optimal design
Document Type: 
Working Paper

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