Please use this identifier to cite or link to this item: https://hdl.handle.net/10419/36583 
Year of Publication: 
2008
Series/Report no.: 
Technical Report No. 2008,09
Publisher: 
Technische Universität Dortmund, Sonderforschungsbereich 475 - Komplexitätsreduktion in Multivariaten Datenstrukturen, Dortmund
Abstract: 
We construct optimal designs for estimating fetal malformation rate, prenatal death rate and an overall toxicity index in a toxicology study under a broad range of model assumptions. We use Weibull distributions to model these rates and assume that the number of implants depend on the dose level. We study properties of the optimal designs when the intra-litter correlation coefficient depends on the dose levels in different ways. Locally optimal designs are found, along with robustified versions of the designs that are less sensitive to mis-specification in the nominal values of the model parameters. We also report e?ciencies of commonly used designs in toxicological experiments and efficiencies of the proposed optimal designs when the true rates have non-Weibull distributions. Optimal design strategies for ?nding multiple-objective designs in toxicology studies are outlined as well.
Subjects: 
Weibull model, dose finding experiment
locally co-optimal design
multipleobjective design
robust optimal design
Document Type: 
Working Paper

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