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Dette, Holger
Biedermann, Stefanie
Zhu, Wei
Year of Publication: 
Series/Report no.: 
Technical Report 2005,02
In dose-response studies, the dose range is often restricted due to ethics concerns over drug toxicity and/or efficacy, particularly when human subjects are involved. We present locally optimal designs for the estimation of several percentiles simultaneously on restricted as well as unrestricted design intervals. Our results are applicable to most of the commonly applied link functions with respect to the model under consideration. This work is a generalization of Dai (2000) where he showed that the same results hold for the logit model using Elfving?s approach on trace optimal design (Elfving, 1952).
Dose-response model
link function
percentile estimation
compound optimal design
Document Type: 
Working Paper
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