During the recent period, the scientific literature has highlighted the role of E-commerce in business development and growth. In this article we revisit the specifics of E-commerce adoption, focusing on the case of Romanian SMEs. Using the online questionnaire survey method and the principal component analysis, we draw a comprehensive picture of Romanian SMEs with E-commerce activities, with reference to the determinants and barriers of E-commerce adoption, benefits emerged with the use of E-commerce and main problems in the E-commerce development. We find that the main factor determining E-commerce adoption is the perceived relative advantage brought by E-commerce activities pointing to higher productivity and efficiency inside the company, while the major barrier is the lack of compatibility between E-commerce activities and the SME's way of doing business, and not the costs, as initially expected. The low competitiveness of the business environment has an important role in deterring E-commerce activity. We conclude that the launch of information campaigns for enhancing familiarity with E-commerce practices for increasing confidence in E-commerce activities for both SMEs managers and their clients is among the most effective measures for intensifying E-commerce activity in Romania.