In this effort an attempt was made to analyse the geographical factors i.e. their objective impact on viniculture and wine tourism in the renowned Tikvesh Basin, which represents a symbol of this type of activities in the Republic of Macedonia. The need of such analysis resulted from the fact that this region comprises 8 % of the Republic's territory and has established itself as an influential agricultural and economic region in the wider vicinity as well. For this purpose adequate methods were utilised such as: mathematical-statistical, cartographic, climatological, touristic, etc. One of the pillars of these research activities, which support the essential postulates of the effort, was the long-lasting terrain exploration. It all points to the final conclusion that the Tikvesh Basin features quite favourable natural and socio-geographical factors which enhance development of vine-growing, winery and wine tourism, whose outstanding potential has only modestly been utilised so far.