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Title:Estimation of the mean AUC of the xenoestrogens daidzein, bisphenol A, and p-tert-octylphenol PDF Logo
Authors:Selinski, Silvia
Degen, Gisela H.
Issue Date:2003
Series/Report no.:Technical Report // Universität Dortmund, SFB 475 Komplexitätsreduktion in Multivariaten Datenstrukturen 2003,05
Abstract:Potentially adverse human and environmental effects due to hormone mimicry of environmental estrogens are a matter of current concern. Environmental estrogens belong to the so-called endocrine active compounds (EAC), which alter signalling processes of the endocrine system leading to a broad range of effects during foetal and postnatal development, puberty, adulthood, and aging. A number of synthetic chemicals as well as several plant-derived compounds, so-called phytoestrogens, are known to have weak estrogenic activity. The present study is part of the risk assessment of the weak environmental estrogens daidzein, p-tert-octylphenol, and bisphenol A. The isoflavone daidzein is an important phytoestrogen with respect to dietary exposure (soy beans and soy products). p-tert-Octylphenol and bisphenol A are industrial chemicals. The toxicokinetics and the bioavailability of these three substances in female DA/Han rats after oral and single intravenous application were investigated by the use of population models accounting for the differences in the individual metabolism. Furthermore, populations of pregnant and non-pregnant rats are compared.
Subjects:Bisphenol A
daidzein
p-tert-octylphenol
xenoestrogens
phytoestrogens
endocrine active compounds
bioavailability
AUC
population model
EM algorithm
Mann-Whitney-U-test
Document Type:Working Paper
Appears in Collections:Technical Reports, SFB 475, TU Dortmund

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